Isagenix IsaPro: “Pre-Sleep” Protein for Muscle Growth


If your goal is muscle growth, you may want to add a second scoop of IsaPro® to your Bedtime Belly Buster. That extra scoop would raise protein to a level consistent with studies evaluating “pre-sleep protein” for boosting muscle protein synthesis.

Muscle protein synthesis is the process the body goes through for either building or rebuilding proteins in the body. The body naturally breaks down and rebuilds muscle protein as part of normal metabolism.

When the rate of muscle breakdown and growth are in balance, the body’s muscle mass stays the same. If the rate of breakdown is greater than the rate of muscle building, then the body starts to lose muscle mass.

The key to muscle growth is for the body to consistently build more muscle protein than it breaks down, resulting in a positive net protein balance. The right combination of nutrition and exercise work together to provide optimal support for muscle growth.

33 Percent Increased Muscle Protein Synthesis

Earlier research found that pre-sleep protein maximized muscle building after evening exercise in young men (1). Additionally, pre-sleep protein had been shown to increase the overall net protein balance necessary for muscle building and growth (2).

Now a new study from the Netherlands reports that older men maximized muscle protein synthesis when they consumed 40 grams of high-quality protein prior to going to bed (3). The study, published in the Journal of Nutrition, randomized participants to either a group that consumed a supplement of 40 grams of protein, 20 grams of protein, or a placebo before sleep. The study then analyzed muscle biopsies prior to and following the protein or placebo ingestion and seven hours of sleep.

Participants who supplemented with 40 grams of protein just prior to sleep had 33 percent higher rates of muscle protein synthesis compared to supplementation with 20 grams or placebo. There was also no significant difference between those who ingested 20 grams of protein versus placebo.

The reason that scientists are interested in sleep is because it’s a critical period for muscle building and recovery. The research suggests that a snack or meal high in protein before going to bed might be a good strategy to for making the most of exercise efforts during the day.

Getting 40 Grams of Protein at Bedtime

A 40-gram dose would be equivalent to about 6 ounces of steak or chicken breast. With Isagenix products, two scoops of IsaPro or one of IsaLean Pro would provide a nearly equivalent dose at 36 grams of protein.

The latest research evaluating pre-sleep protein is also supported by recent research  conducted at Skidmore College that evaluated use of Isagenix protein-rich products for improving athletic performance (4, 5). In those studies, subjects had either a protein-rich IsaLean Bar or other product that was rich in whey protein just before bed (4, 5).

Not everyone may be interested in getting 40 grams of protein before bed. If your goal is weight loss, 20 grams of protein 30-60 minutes before bed may be just the boost your metabolism needs. But If you’re looking to build muscle and strength, increasing the protein to 40 grams before bed might be the right dose for you.


  1. Snijders T, Res PT, Smeets JSJ, et al. Protein ingestion before sleep increases muscle mass and strength gains during prolonged resistance-type exercise training in healthy young men. Journal of Nutrition. 2015 Jun; 145(6): 1178-1184. doi: 10.3945/jn.114.208371.
  2. Holwerda AM, Kouw IWK, Trommelen J, et al. Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men. Journal of Nutrition. 2016 Jul; 146(7): 1307-1314. doi: 10.3945/jn.116.230086.
  3. Kouw IWK, Holwerda AM, Trommelen J, et al. Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: a randomized controlled trial. Journal of Nutrition. 2017 Aug 30. jn254532. doi: 10.3945/jn.117.254532.
  4. Ives SJ, Norton C, Miller V, Minicucci O, et al. Multi-modal exercise training and protein-pacing enhances physical performance adaptations independent of growth hormone and BDNF but may be dependent on IGF-1 in exercise-trained men. Growth Horm IGF Res. Oct; 24.  DOI: http://dx.doi.org/10.1016/j.ghir.2016.10.002
  5. Arciero PJ, Ives SJ, Norton C, et al. Protein-Pacing and Multi-Component Exercise Training Improves Physical Performance Outcomes in Exercise-Trained Women: The PRISE 3 Study. Nutrients. 2016 Jun 1;8(6).


Offset Muscle Loss

Using IsaPro to increase your protein intake can help prevent age-related muscle loss.

Perfect for Athletes

IsaPro is designed to complement high-protein diets and be used as a post-workout shake for muscle recovery.

Break That Plateau

Using IsaPro to boost protein intake can help conquer stubborn weight loss plateaus.

Isagenix Performance Products :
Now Carry The Informed-Sport Certification

Anna Nordqvist, Team Isagenix Elite Athlete and 7-Time LPGA Tour Winner

The possibility of substances banned by the World Anti-Doping Agency (WADA) in sports supplements is surprisingly high. Researchers estimate that somewhere between 3-25 percent of sports products contain traces of banned substances that are not present on the label.*

At Isagenix, we produce products that are safer for athletes all over the world. For this reason, we are pleased to announce that the AMPED™ line (as well as other performance-focused Isagenix products) are now Informed-Sport Certified. Everyone from competitive athletes to everyday performance enthusiasts can feel confident knowing that their Isagenix products have been tested for banned substances.

*Source: Judkins CMG, Teale P, and Hall DJ. The role of banned substance residue analysis in the control of dietary supplement contamination. Drug Testing and Analysis. 2010 Sep;2(9):417-20.


    IsaPro contains 18 grams of high-quality, undenatured whey protein concentrate. Available in Vanilla and NEW Chocolate!


    Extra protein is necessary for anyone starting a weight-loss or work out program, trying to break through a weight-loss plateau, or dealing with muscle mass and function loss. When you need more protein, IsaPro is the perfect addition to any meal.


    Whey is the most effective protein for building and maintaining lean muscle with a complete branched-chain amino acid profile.


    IsaPro is one of the most versatile protein products we offer. Use as a protein boost to your smoothies, mix with water for a post-workout shake, or add to a fun recipe to change it up. There are so many unique and exciting ways to enjoy IsaPro!

    Please visit our Isagenix store: www.ChampionsNutrition.com.  Thank you.


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