Study Finds More Reason to Share the Isagenix e-Shot


e+™ Energy Shot, a flavorful energy shot with naturally sourced caffeine and adaptogens, boosts energy without the negative side effects associated with other highly caffeinated supplements.

A recent clinical study from Clarkson University reported mental performance benefits of e+. Presented at the American Society for Nutrition’s annual meeting in Boston, Massachusetts, the study evaluated the effects of e+ on cognitive responses, mood, and physiological measures.

“One feature of this study that made it particularly novel was our use of two placebos – a regular placebo and a placebo containing synthetic caffeine to match the content of e+,” said Assistant Professor of Physical Therapy at Clarkson and lead author of the study Ali Boolani, Ph.D. “This allowed us to compare the effects of the naturally sourced caffeine and adaptogenic herbs of e+ to the synthetic caffeine of the placebo.”

Study Details

The study included 30 male and female participants, averaging 21 years of age, who met a strict criteria of caffeine use. Performing the mental tasks involved, each subject completed 30 minutes of baseline testing prior to consuming a regular placebo, a caffeinated placebo, or an e+. After consumption of their assigned product, each subject undertook a new series of mental tasks to measure the effect of the product on various cognitive and mental performance along with mood.  The subjects waited a period of at least 48 hours between testing each product.

The study also analyzed physiological measures such as blood pressure, heart rate, and cortisol. (The cortisol data was not presented at the conference but will be present in the manuscript being written for peer-reviewed publication).


The results of the study demonstrated that none of the products affected heart rate or blood pressure. In contrast, both the caffeinated placebo and e+ increased mental performance and feelings of vigor. Interestingly, the effects of the caffeinated placebo were immediate before declining, whereas e+ resulted in a  slower, more gradual increase in these measures and did not decline.

The caffeinated placebo also resulted in a significant increase in tension and anxiety.

“These results suggest that adaptogenic herbs appear to improve some aspects of mental performance while perhaps minimizing some of the less desirable effects seen by caffeine alone,” said manager of Isagenix Research and Science and a co-author of the study Eric Gumpricht, Ph.D. “To what degree the source of caffeine affects these findings are unknown.”

e+ Energy Shot: A Natural Way to Energize

With 35 calories per serving and no artificial colors, sweeteners, or flavors, e+ is designed to support long-lasting energy and performance with plant-based caffeine and adaptogens.



A long-lasting, flavorful energy shot made with naturally sourced, plant-based caffeine and Adaptogens.

  • 35 calories per serving
  • Fuel your everyday and athletic activities
  • No artificial colors, sweeteners, or flavors

Fights Low Energy

Life is difficult when you’re low on energy. e+ boosts energy, fights low energy, and can improve athletic performance, all without any artificial flavors, colors, or sweeteners.*

Natural Energy

e+ combines a scientifically supported blend of botanicals and plant-based caffeine from green tea and yerba mate to help you feel energized and mentally alert.*

Give Back

For every box of e+ sold, Isagenix donates 50 cents to Make-A-Wish®.

What is e+?

A long-lasting and flavorful energy shot, made with naturally sourced plant-based caffeine and Adaptogens.

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What makes e+ unique?

e+ is a natural energy shot featuring our Adapto+™, a selection of Adaptogens ideal for combating stress, providing clarity, and promoting physical performance.* The addition of naturally sourced caffeine derived from green tea and yerba mate provides energy to help kick-start your workout or power you through a busy day.

Who is e+ designed for?

e+ is designed for those ages 16 and older who are looking to kick-start a workout, boost their mental and/or physical performance, increase their body’s capacity to perform better under stressful circumstances, or enhance physical activity and recovery.*

Why should I choose e+ over other energy shots?

Many energy shots have high levels of caffeine, which could potentially cause unwelcomed side effects. They may also use too much sugar or artificial sweeteners, flavors, and coloring. In addition, no other energy shot on the market contains our proprietary Adaptogen botanical blend.

How long will the effects of e+ last?

The ingredients in e+ can affect individuals differently. We recommend using one half of a bottle, or 1 ounce, for moderate energy and a whole bottle, or 2 ounces, for maximum energy, with a maximum of two bottles daily. To discover how e+ works for you, begin with drinking one half of a bottle, wait 10 minutes, and determine if you require more. If you have any medical conditions, are pregnant, nursing, diabetic, on medication or otherwise have concerns if e+ is right for you, please check with your physician before taking this or any other supplement.

Isagenix Performance Products Now Carry The Informed-Sport Certification

Anna Nordqvist, Team Isagenix Elite Athlete and 7-Time LPGA Tour Winner

The possibility of substances banned by the World Anti-Doping Agency (WADA) in sports supplements is surprisingly high. Researchers estimate that somewhere between 3-25 percent of sports products contain traces of banned substances that are not present on the label.*

At Isagenix, we produce products that are safer for athletes all over the world. For this reason, we are pleased to announce that the AMPED™ line (as well as other performance-focused Isagenix products) are now Informed-Sport Certified. Everyone from competitive athletes to everyday performance enthusiasts can feel confident knowing that their Isagenix products have been tested for banned substances.

*Source: Judkins CMG, Teale P, and Hall DJ. The role of banned substance residue analysis in the control of dietary supplement contamination. Drug Testing and Analysis. 2010 Sep;2(9):417-20.


Boolani A, Grobe S, Josephs D, Smith M, and Gumpricht E. Acute effects of caffeine-containing adaptogenic-rich natural beverage on sustained attention, mood, heart rate, blood pressure and fine motor skills. Presented at American Society for Nutrition, Nutrition 2018 conference, June 9-13, 2018.

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